解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Alcohol dependence (AD) affects individuals from all racial/ethnic groups, and previous research suggests that there is considerable variation in AD risk between and among various ancestrally defined groups in the United States. Although the reasons for these differences are likely due in part to contributions of comp...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12578
更新日期:2019-01-01 00:00:00
abstract::Although our previous studies have demonstrated both protein kinase C (PKC) and GluN2B-containing N-methyl-d-aspartate receptor (GluN2B-NMDAR) play crucial roles in morphine-associated learning and memory, the relationship between them remains unexplored. In this study, we validated the enhanced PKC and membrane GluN2...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12558
更新日期:2018-09-01 00:00:00
abstract::Reduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel-based morphometric analysis with diffeomorphic anatomica...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12552
更新日期:2018-09-01 00:00:00
abstract::It has been hypothesized that neural reactivity to drug cues in certain limbic/paralimbic regions of the brain is an indicator of addiction severity and a marker for likelihood of success in treatment. To address this question, in the current study, 32 participants (44 percent female) completed a functional magnetic r...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12549
更新日期:2018-09-01 00:00:00
abstract::Mixing alcohol with caffeinated energy drinks is a common practice, especially among young people. In humans, the research on this issue has mainly focused on the use of the mass-marketed energy drinks themselves, whereas in animal models, it has focused on the individual effects of their active ingredients (i.e. caff...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12560
更新日期:2018-09-01 00:00:00
abstract::Poor working memory is linked to future risk-taking behaviors. Lifelong risk of habitual drug use is highest in individuals who initiate use in early adolescence. We sought to determine in rats whether juvenile traits, specifically poor working memory and low salivary brain-derived neurotrophic factor (BDNF), are rela...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12535
更新日期:2018-05-01 00:00:00
abstract::Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine signaling downstream from the ventral tegmental area (VTA). The VTA dopam...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12514
更新日期:2018-03-01 00:00:00
abstract::Neuroimaging of opiate-dependent individuals indicates both altered brain structure and function. Magnetic resonance-based arterial spin labeling has been used to measure noninvasively cerebral blood flow (i.e. perfusion) in alcohol, tobacco and stimulant dependence; only one arterial spin labeling paper in opiate-dep...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12523
更新日期:2018-03-01 00:00:00
abstract::Although adolescents are a group heavily targeted by the e-cigarette industry, research in cue-reactivity has not previously examined adolescents' behavioral and neural responses to e-cigarette advertising. This study addressed this gap through two experiments. In Experiment One, adult traditional cigarette smokers (n...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12510
更新日期:2018-03-01 00:00:00
abstract::Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme responsible for the degradation of the endocannabinoid anandamide and other non-cann...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12531
更新日期:2018-03-01 00:00:00
abstract::Obesity represents an important risk factor contributing to the global burden of disease. The current obesogenic environment with easy access to calorie-dense foods is fueling this obesity epidemic. However, how these foods contribute to the progression of feeding behavior changes that lead to overeating is not well u...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12595
更新日期:2018-03-01 00:00:00
abstract::Alterations in neural structure have been reported in both cocaine-use disorder and gambling disorder, separately, suggesting similarities across addiction diagnoses. Individual variation in neural structure has also been associated with impulsivity, a dimensional construct implicated in addictions. This study combine...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12492
更新日期:2018-01-01 00:00:00
abstract::This study evaluated the effects of cannabidiol (CBD) on ethanol reinforcement, motivation and relapse in C57BL/6 J mice. The effects of CBD (60 mg/kg, i.p.) on blood ethanol concentration, hypothermia and handling-induced convulsions associated to acute ethanol administration were evaluated. The two-bottle choice par...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12495
更新日期:2018-01-01 00:00:00
abstract::Exposure to smoking-associated environmental cues during smoke cessation elicits self-reported urge/craving to smoke, which precipitates relapse even after prolonged abstinence. Incubation of cue-induced cigarettes craving during abstinence has been observed in human smokers recently. The present studies assessed cue-...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12480
更新日期:2018-01-01 00:00:00
abstract::Cocaine self-administration in rats results in dysfunctional neuroadaptations in the prelimbic (PrL) cortex during early abstinence. Central to these adaptations is decreased phospho-extracellular signal-regulated kinase (p-ERK), which plays a key role in cocaine seeking. Normalizing ERK phosphorylation in the PrL cor...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12504
更新日期:2018-01-01 00:00:00
abstract::Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both food-reinforced behaviors and behavior motivated by drugs of abuse. However, the relative role of the Orx/Hcrt system in behavior motivated by food versus drugs of abuse remains unclear. This investigation addressed this question by contrast...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12441
更新日期:2018-01-01 00:00:00
abstract::Hangover refers to the cluster of physiological and behavioral symptoms that occur following the end of a drinking episode. While hangover has been studied after the typical oral consumption of alcohol, the occurrence of hangover following intravenous (IV) alcohol administration in human laboratory studies has not bee...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12469
更新日期:2018-01-01 00:00:00
abstract::Long-term alcohol use affects cognitive and neurophysiological functioning as well as structural brain development. Combining simultaneous electroencephalogram (EEG) recording with transcranial magnetic stimulation (TMS) enables direct, in vivo exploration of cortical excitability and assessment of effective and funct...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12486
更新日期:2018-01-01 00:00:00
abstract::We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, and addiction to nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs for 144 609 subjects, including 10 036 individuals admitted for in-patient addiction treatment and 35 ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12496
更新日期:2018-01-01 00:00:00
abstract::Alcoholism is a chronic relapsing disorder, and stress is a key precipitant of relapse. The nucleus incertus (NI) is highly responsive to corticotrophin-releasing factor (CRF) and psychological stressors, receives a CRF innervation and expresses CRF1 and CRF2 receptor mRNA. Furthermore, the ascending NI relaxin-3 syst...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12426
更新日期:2017-11-01 00:00:00
abstract::Withdrawal from extended-access cocaine self-administration leads to progressive intensification ('incubation') of cocaine craving. After prolonged withdrawal (1-2 months), when craving is high, expression of incubation depends on strengthening of excitatory inputs to medium spiny neurons (MSN) of the nucleus accumben...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12430
更新日期:2017-11-01 00:00:00
abstract::Caffeine has cognitive-enhancing properties with effects on learning and memory, concentration, arousal and mood. These effects imply changes at circuital and synaptic level, but the mechanism by which caffeine modifies synaptic plasticity remains elusive. Here we report that caffeine, at concentrations representing m...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12433
更新日期:2017-11-01 00:00:00
abstract::Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12428
更新日期:2017-11-01 00:00:00
abstract::Based on the knowledge that alcohol misuse causes a multitude of diseases and increased mortality, this systematic review examines whether a reduction of the individual alcohol consumption can contribute to a minimization of health risks within a harm reduction approach. In fact, the reviewed 63 studies indicate that ...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12414
更新日期:2017-09-01 00:00:00
abstract::Methamphetamine (METH) markedly increases dopamine (DA) release in the mesolimbic DA system, which plays an important role in mediating the reinforcing effects of METH. METH-induced DA release results in the formation of reactive oxygen species (ROS), leading to oxidative damage. We have recently reported that ROS are...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12419
更新日期:2017-09-01 00:00:00
abstract::In light of the upcoming eleventh edition of the International Classification of Diseases (ICD-11), the question arises as to the most appropriate classification of 'Pathological Gambling' ('PG'). Some academic opinion favors leaving PG in the 'Impulse Control Disorder' ('ICD') category, as in ICD-10, whereas others a...
journal_title:Addiction biology
pub_type: 杂志文章,评审
doi:10.1111/adb.12378
更新日期:2017-07-01 00:00:00
abstract::Studies conducted in drug addiction suggest a transition in processing of drug-related cues from the ventral to the dorsal component of the striatum. However, this process has not been studied in a behavioral addiction. Assessment of this process in a non-drug addiction can provide insight into the pathophysiology of ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12338
更新日期:2017-05-01 00:00:00
abstract::The posterior hippocampus (pHp) plays a major role in the processing and storage of drug-related cues and is linked to striatal-limbic brain circuits involved with craving and drug salience. We have recently reported that increased basal regional cerebral blood flow (rCBF) in a pHp loci, as measured by pseudo-continuo...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12361
更新日期:2017-05-01 00:00:00
abstract::Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the hu...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12356
更新日期:2017-05-01 00:00:00
abstract::The drive to eat is regulated by two compensatory brain pathways termed as homeostatic and hedonic. Hypothalamic orexinergic (ORX) neurons regulate metabolism, feeding and reward, thus controlling physiological and hedonic appetite. Circadian regulation of feeding, metabolism and rhythmic activity of ORX cells are dri...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12339
更新日期:2017-03-01 00:00:00
abstract::We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12294
更新日期:2017-01-01 00:00:00
abstract::Addiction is characterized by a persistent loss of behavioral control resulting in insensitivity to negative feedback and abnormal decision-making. Here, we investigated the influence of methamphetamine (METH)-paired contextual cues on decision-making in rats. Choice between goal-directed actions was sensitive to outc...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12316
更新日期:2017-01-01 00:00:00
abstract::This invited commentary on the paper 'White Matter Connectivity and Internet gaming disorder' by Jeong et al. (unpublished) looks at the implications and importance of the MRI findings in the present study-one of the largest to date-and also considers the broader developments of neuroimaging within the complex, emergi...
journal_title:Addiction biology
pub_type: 评论,杂志文章
doi:10.1111/adb.12265
更新日期:2017-01-01 00:00:00
abstract::Adolescence is characterized by considerable brain maturation that coincides with the development of adult behavior. Binge drinking is common during adolescence and can have deleterious effects on brain maturation because of the heightened neuroplasticity of the adolescent brain. Using an animal model of adolescent in...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12232
更新日期:2016-07-01 00:00:00
abstract::Neuroimaging studies suggested that drug addiction is linked to abnormal brain functional connectivity. However, little is known about the alteration of brain white matter (WM) connectivity in addictive drug users and nearly no study has been performed to examine the alterations of brain WM connectivity in heroin-depe...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12234
更新日期:2016-05-01 00:00:00
abstract::Internet use and on-line game play stimulate corticostriatal-limbic circuitry in both healthy subjects and subjects with Internet gaming disorder (IGD). We hypothesized that increased fractional anisotropy (FA) with decreased radial diffusivity (RD) would be observed in IGD subjects, compared with healthy control subj...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12246
更新日期:2016-05-01 00:00:00
abstract::The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this functional magnetic resonance imaging (fMRI) study, we examined resting-state functional connectivity (rsFC) of the insula and its associ...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12247
更新日期:2016-05-01 00:00:00
abstract::The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consum...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12277
更新日期:2016-03-01 00:00:00
abstract::Behavioral sensitization to cocaine is associated to neuroadaptations that contribute to addiction. Enkephalin is highly expressed in mesocorticolimbic areas associated with cocaine-induced sensitization; however, their influence on cocaine-dependent behavioral and neuronal plasticity has not been explained. In this s...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12200
更新日期:2016-03-01 00:00:00
abstract::Through incentive learning, the emotional experience of a reward in a relevant need state (e.g. hunger for food) sets the incentive value that guides the performance of actions that earn that reward when the need state is encountered again. Opiate withdrawal has been proposed as a need state in which, through experien...
journal_title:Addiction biology
pub_type: 杂志文章
doi:10.1111/adb.12172
更新日期:2016-03-01 00:00:00